Phospholipidosis heart

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August undefined, 2024

WebPhospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is … WebPhospholipidosis (PLD) is characterized by the excessive intracellular accumulation of phospholipids. It is well established that a large number of cationic amphiphilic drugs have the potential to induce PLD. In the present study, we describe two facile in vitro methods to determine the PLD-inducing potential of a molecule.

Drug-induced Phospholipidosis -Pathological Aspects and Its …

WebMar 24, 2024 · Drug-induced phospholipidosis: Human: ASCs: Matrigel: Expression of CYP450 enzyme (CYP3A4); ... heart, and kidney.86 Yang et al57 showed that human PSC (hPSC)–derived hepatocyte and cholangiocyte organoids expressing angiotensin 1 converting enzyme 2 (ACE2, a putative receptor of SARS-CoV-2) were highly permissive to … WebCationic amphiphilic drugs (CADs) include hundreds of FDA-approved agents used to treat a broad spectrum of common diseases, including psychiatric disorders, allergies, heart diseases and infections 6. CADs are characterized by a hydrophobic aromatic ring or ring system and a hydrophilic side chain containing an ionizable amine functional group 7. simple sweater coat knitting pattern

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WebLipid Management services at the Massachusetts General Hospital Corrigan Minehan Heart Center care for patients who have disorders of lipid metabolism, which include high … WebNov 29, 2016 · Phospholipidosis induced by drugs with a cationic amphiphilic structure is a generalized condition in humans and animals that is characterized by an intracellular … WebPhospholipidosis (PLD) is characterized by excessive intra-cellular accumulation of phospholipids, with a distinct mor - phological appearance of lamellar bodies visible under an electron microscope (EM).1 Drugs, including many antibi-otics, antidepressants, and antihistamines, induce PLD in various tissues such as lung,2 heart,3 liver,4 and ... raye love me again

Drug-induced Phospholipidosis -Pathological Aspects and Its …

National Center for Biotechnology Information

WebDec 18, 2024 · Abstract. Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of phospholipids. Its cellular mechanism is still … WebMar 23, 2024 · Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2 Drug-induced phospholipidosis is a single mechanism that may explain the in vitro efficacy of a wide-variety of therapeutics repurposed for COVID-19. ray elwenniWebNov 27, 2024 · Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA; 2. ... thus, marked phospholipidosis in our patient’s LV cardiomyo- rayel services

"WebDec 14, 2009 · Phospholipidosis in neurons, the heart, or the eyes might generate more safety concerns. A drug that has the potential to induce PL in terminally differentiated organs such as the eye, the heart, and neurons may require additional monitoring in … " - Phospholipidosis heart

Phospholipidosis heart

Liver organoids: established tools for disease modeling and drug ...

Webphospholipidosis and on a 10-fold cross-validation test produced {76% positive, 78% negative predictivity} and {65% positive, 87% negative predictivity}, respectively. All these approaches are based on relatively simple models, and as phospholipidosis is clearly a complex effect, applying state of the art machine learning techniques could therefore WebMar 24, 2024 · Correlations between phospholipidosis (DIPL), normalized to amiodarone at 100%, and percent of SARS-CoV-2, normalized to DMSO at 100%, in the RT-qPCR assay in A549-ACE2 cells. ... National Heart ...

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WebDrug-induced phospholipidosis (PLDsis) is an excessive accumulation of polar phospholipids in cells or tissues/organs caused by xenobiotics. Numerous drugs and chemicals are capable of inducing the storage disorder in animals and humans; however, despite their diverse pharmacological activities, each of these drugs shares common … WebNational Center for Biotechnology Information

WebFeb 22, 2024 · The topic of lysosomal accumulation was chosen for several reasons: (1) this change is frequently encountered in nonclinical toxicity studies (Logan et al. 2012) due to the central role of lysosomes in cellular uptake, storage, intracellular trafficking, and digestion of endogenous and exogenous material; (2) it is caused by a wide variety of … WebJan 20, 2024 · Phone: 734-449-1190 Mucolipidosis IV (ML 4) Foundation Phone: 877-654-5459 National MPS Society Phone: 919-806-0101 National Organization for Rare …

WebDec 1, 2006 · A 76-year-old male Caucasian patient was treated in our hospital for acutely decompensated heart failure due to restrictive cardiomyopathy. ... Drug-induced phospholipidosis is characterized by ... WebPhospholipidosis (PL) is a phospholipid storage disorder, resulting in excessive accumulation of phospholipids in lysosomes of various tissue types [199, 200]. There is a general agreement that inhibition of lysosomal phospholipase A1, A2 and/or C contributes to the accumulation of cationic amphiphilic drug (CADs)–phospholipid complexes.

WebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well established 1 that a large number of cationic amphiphilic drugs have the potential to induce phospholipidosis.

WebJan 21, 2024 · Fabry disease (FD) is a genetic disorder caused by a-galactosidase A gene mutation. Ultrastructural analysis revealing zebra bodies are the typical morphological characteristics. However, certain tricyclic antidepressants and some other medications could induce renal phospholipidosis mimicking FD. We report a 33-year-old man has been … raye love of your life lyricsWebIn most cases, children with hypoplastic left heart syndrome appear healthy at birth. When a baby is not diagnosed during pregnancy, symptoms may develop within the first few … simple swedish meatball gravyWebOct 9, 2006 · The term drug-induced phospholipidosis ascribes to a condition that has been defined by the appearance of intracellular accumulation of phospholipids and lamellar bodies. Beyond this definition, each CAD induces its own specific phospholipid composition and selectively targets organs. simple sweet and sour chickenWebMar 24, 2024 · Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2 bioRxiv bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive. simple swedish meatball sauceWebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. Certain cases may be triggered by medications. … rayel walker realtorWebMar 24, 2024 · Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. Phospholipidosis is a shared … raye love of your lifeWebNov 27, 2024 · An endomyocardial biopsy of the left ventricle (LV) demonstrated no inflammatory cell infiltration, however, electron microscopy examination later revealed significant phospholipidosis, demonstrating intracellular accumulation of phospholipids with lysosomes appearing as lamellar bodies ( Panel C, area surrounded by yellow asterisks, … simple swedish meatballs