Osthole 藥理作用

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August undefined, 2024

WebOct 1, 2024 · Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. It can be obtained … WebDec 31, 2024 · Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide spectrum of pharmacological effects, thus its anti-inflammatory potential in the LPS-treated Caco-2 cell line as well as in Caco-2/THP-1 and Caco-2/macrophages co …

Osthole SpringerLink

WebAug 5, 2024 · Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. It can be obtained … WebOsthole inhibits the cell proliferation of gastric cancer cells To assess the anti-gastric cancer activity of osthole (Fig 1A), HGC-27 and SGC-7901 cells were treated with the indicated concentrations of osthole for 48 h, and the cell viability was examined using MTT assay. As shown in Fig 1B, osthole inhibited the cell viability of tris trimethylsilyl phosphite

Osthole: A Review on Its Bioactivities, Pharmacological ... - Hindawi

WebOsthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H 1 receptor activity. Osthole also suppresses the secretion of HBV in cells. Osthole (p<0.0001) and Fexofenadine (p<0.001) inhibit increased HRH-1 mRNA expression induced by histamine in the study group. WebJan 17, 2024 · Up to date, there is no report of osthole’s side effects on cancer treatment, so osthole is a safety and effective tumor suppressor. Moreover, osthole could successfully inhibit tumor synergistically with a relatively low and safe Gy X-ray radiations for cellular or animal model, since we did not find any side effects for all mice treatment with X-ray … WebApr 11, 2024 · Osthole, a naturally occurring coumarin-type compound, is isolated from the Chinese herbal medicine Cnidium monnieri (L.) and exhibits a broad range of biological properties. In this review, the total synthesis and structural modifications of osthole and its analogs are described. Additionally, the progress on bioactivities of osthole and its … tris tromethamine

Osthole - an overview ScienceDirect Topics

Osthole: an overview of its sources, biological activities, and ...

WebOsthole, an O-methylated coumarin, exhibits a myriad of biochemical properties and its derivative, furo [3,2-c ]coumarin is capable of forming covalent bonds with DNA and other biological macromolecules, 72 e.g., Wedelolactone (antihepatotoxic), 73 Angelicin (anticancer, antiviral, anti-inflammatory) 74–76. WebActive constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities.Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of … tris trimethylsilyl phosphineWebAug 23, 2024 · Metastasis is the leading cause of death in breast cancer patients. Osthole, as an active compound detected in the traditional Chinese medicine Wenshen Zhuanggu Formula, has shown a promising anti ... tris trimethylsilyl silane nmr

"WebFeb 14, 2024 · Osthole, a naturally occurring coumarin-type compound, is isolated from a Chinese herbal medicine Cnidium monnieri (L.), and exhibits a broad range of biological properties. In this review, the ... " - Osthole 藥理作用

Osthole 藥理作用

Osthole regulates secretion of pro-inflammatory cytokines JIR

WebIntroduction. Osthole (OST) (7-methoxy-8-(3-methyl-2-butenyl)coumarin) is a natural compound isolated from Cnidium plants and commonly used in Chinese medicine to improve immune system functions. 1 OST possesses a broad spectrum of pharmacological properties: anti-allergic, 2 anti-inflammatory, 2 anti-tumor, 3–5 hepatoprotective, 6–8 … WebJul 13, 2015 · This paper reviews the latest understanding of biological and pharmacological properties of osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural …

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WebMay 13, 2015 · Abstract. This paper reviews the latest understanding of biological and pharmacological properties of osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural product found in several medicinal plants such as Cnidium monnieri and Angelica pubescens.In vitro and in vivo experimental results have revealed that osthole … WebAug 1, 2015 · Background Hepatic fibrosis is a dynamic process which ultimately leads to cirrhosis in almost patients with chronic hepatic injury. However, progressive fibrosis is a reversible scarring response. Activation of hepatic stellate cells (HSCs) is the prevailing process during hepatic fibrosis. Osthole is an active component majorly contained in the …

WebApr 11, 2024 · Osthole, a naturally occurring coumarin-type compound, is isolated from the Chinese herbal medicine Cnidium monnieri (L.) and exhibits a broad range of biological … WebOsthole significantly increased BMD in osteoporotic rats. Subgroup analysis demonstrated that the increase in BMD varied with dose and duration of osthole treatment. The increase …

WebJun 1, 2010 · Subcutaneous injection of Osthole at a dose of 5 mg/kg per day onto mouse calvariae significantly stimulated local bone formation, as shown by histologic analysis of calvarial samples harvested 2 weeks after the last injection and stained with H&E orange G. Histomorphometric analysis revealed that Osthole had a significant effect on bone … WebOsthole C15H16O3 CID 10228 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …

WebApr 24, 2024 · In the current study, we identified a plant compound, osthole that inhibits mast cell-MRGPRX2/MrgprB2 mediated responses in vitro and in vivo. Specifically, osthole significantly attenuates both the early (Ca 2+ mobilization and degranulation) and delayed phases (chemokine/cytokine production) of mast cell activation.

WebApr 21, 2024 · Objective . To study the mechanism of osthole in GC based on network pharmacology and molecular docking. Methods . The potential targets of osthole were … tris tysonWebAbstract. Context: Osthole is a natural coumarin compound most frequently extracted from plants of the Apiaceae family such as Cnidium monnieri (L.) Cusson, Angelica pubescens … tris unblockedWebApr 21, 2024 · Objective . To study the mechanism of osthole in GC based on network pharmacology and molecular docking. Methods . The potential targets of osthole were predicted through the TCM System Pharmacology Analysis Platform, SwissTargetPrediction, and PharmMapper database. Targets related to gastric cancer were obtained through … tris urban dictionaryWebNational Center for Biotechnology Information tris turnerWebOsthole has been reported to regulate various signaling pathways, which in turn modulate several apoptosis-related proteins, cell cycle regulators, protein kinases, transcriptional factors, cytokines, and growth receptors affiliated with inflammation, proliferation and several other ailments. tris vs computerWebMar 28, 2024 · Osthole is an active compound isolated from Chinese herb Cnidium monnieri (L.) Cusson, and had been reported to possess antitumor effect. However, the effect of … tris viscosityWeb第十五局改正日本薬局方適合生薬試験用 (標品) オストール. オストールはジャショウシの確認試験用標品です。. ジャショウシはオカゼリ科の果実で、収れん性消炎薬として用い … tris und four